paper · Salvador Luria / Max Delbrück · tradition: evolutionary-dynamics

Luria & Delbrück (1943), the fluctuation test: the wide variance in resistant-bacteria counts across parallel cultures showed mutations arise spontaneously before the selective pressure (the virus), not in adaptive response to it. Variation proposes blind, and only afterward does selection choose — grounding the book’s claim that the generate step runs blind.

The book’s stance. evidentiary grounding for blind variation preceding selection in Chapter 5b.

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